Progressive Motor Cortex Functional Reorganization Following 6-Hydroxydopamine Lesioning in Rats
نویسندگان
چکیده
منابع مشابه
Progressive motor cortex functional reorganization following 6-hydroxydopamine lesioning in rats.
Many studies have attempted to correlate changes of motor cortex activity with progression of Parkinson's disease, although results have been controversial. In the present study we used intracortical microstimulation (ICMS) combined with behavioral testing in 6-hydroxydopamine hemilesioned rats to evaluate the impact of dopamine depletion on movement representations in primary motor cortex (M1)...
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In the rat several paradigms of grafting of adrenal medulla into the striatum were studied following the induction of a parkinsonian model, using a unilateral 6-hydroxydopamine (6-OHDA) lesion of the substantia nigra. Direct autologous grafting of adrenal medulla into the caudate-putamen complex, a radiofrequency lesion of the striatum alone, and a radiofrequency lesion followed by delayed graf...
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Kleim, Jeffrey A., Scott Barbay, and Randolph J. Nudo. Funcchanges in movement topography were observed in the rat tional reorganization of the rat motor cortex following motor skill motor cortex in response to manipulations of sensory input learning. J. Neurophysiol. 80: 3321–3325, 1998. Adult rats were (Huntley 1997; Keller et al. 1996), peripheral denervation allocated to either a skilled or...
متن کاملFunctional reorganization of the rat motor cortex following motor skill learning.
Functional reorganization of the rat motor cortex following motor skill learning. J. Neurophysiol. 80: 3321-3325, 1998. Adult rats were allocated to either a skilled or unskilled reaching condition (SRC and URC, respectively). SRC animals were trained for 10 days on a skilled reaching task while URC animals were trained on a simple bar pressing task. After training, microelectrode stimulation w...
متن کاملRapid functional reorganization in human cortex following neural perturbation.
Despite the human brain's ability to rapidly reorganize neuronal activity patterns in response to interactions with the environment (e.g., learning), it remains unclear whether compensatory mechanisms occur, on a similar time scale, in response to exogenous cortical perturbations. To investigate this, we disrupted normal neural function via repetitive transcranial magnetic stimulation and asses...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2011
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.5394-10.2011